Growth Mechanisms & Science

Important: Osstivia is both dose and time dependent. Consistent application is required to trigger the growth pathways.

• Targeted Pathways. Osstivia acts directly on the critical bone modulation pathways including Bmp2, Runx2, Rankl, and others.
• Canonical Wnt Modulation. The enhanced Fructus Ligustri Lucidi in the formulation specifically modulates the canonical Wnt/β-catenin pathway, which is essential for osteogenesis.
• Anabolic Shift. Research indicates a positive shift in bone turnover markers: increasing Osteocalcin (OCN) for formation while decreasing CTX-I (a marker of bone resorption).
• Growth Plate Preservation. Recent findings indicate that FLL preserves growth plate quality, with studies showing an increase in growth plate cartilage thickness by ~24% to 32% compared to controls.

Mandatory Synergy Protocol

Osstivia provides the boost, but mechanical loading provides the results. For facial aesthetics and condyle growth & remodeling (as well as zygomatic improvements), hard chewing is mandatory.

• 30 Minute Limit. Chew for a total of 30 minutes a day. Do NOT chew for hours or constantly clench, as this leads to TMJD and has negative effects on the condyle.
• Cheekbone & Mandible. Hard chewing grows and remodels the condyle, which leads to greater improvements in the mandible. Osstivia helps with forward growth and CCW rotation of mandible under specific circumstances like malocclusion and a good tough chewing regimen. Some zygo and mandible improvements may be possible but it needs to be looked into further. Basically, Osstivia boosts hard chewing results and reduces the time to get those results.
• Growth Potential. Hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible so keeping bone health up definitely helps take advantage of that. If it increases proliferation, which Osstivia does, it would be enough to boost chewing results. You're not done remodeling the condyle even after your 60s. However, growth is most potent now, so take advantage of being young and hard chew.
• Timing. Take Osstivia 10–20 minutes BEFORE your hard chewing session for maximum uptake.

How to Chew Correctly (Hard Gum)

• Form & Focus. Open mouth while chewing. Don’t be distracted; focus on the movement.
• Technique. Chew bilaterally (both sides). Position the gum, bite a couple of times, roll the gum with your tongue, and repeat.
• Pacing & Rest. Take rests in between. For example, chew for 1 minute, then rest for 45s–1 min. Rinse and repeat until you hit 30 minutes. Do NOT chew for more than 30 minutes total (including rest time).
• Keep it Tough. If the gum gets soft, use ice water and let it sit in your mouth for a couple of seconds, then resume chewing.
• Safety Note. If you have an overbite, contact the Craniofacial Research Collective (CRC) first before chewing.

Care, Usage & Taste Profile

• Do NOT: Do not refrigerate. Do not place near the sun. Do not put in super warm liquids. Do NOT shake if the product is already diluted.
• You CAN: Take Osstivia by itself or put it in water to drink. You can drink other beverages before or after taking it. You can shake the bottle before use (undiluted).
• Taste Profile. This is an advanced formulated product; it does not taste sugary or fake. Some users are sensitive to the excipients, while others don't mind. It is an acquired taste you will get used to.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.

How long will your bottle last?

Scientific References

• Fructus ligustri lucidi ethanol extract improves bone mineral density and properties through modulating calcium absorption-related gene expression in kidney and duodenum of growing rats. Calcif Tissue Int. (2014).
• The advances in research on the pharmacological effects of Fructus Ligustri Lucidi. Biomed Res Int. (2015).
• Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri Lucidi. Br J Nutr. (2008).
• Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). (2019).
• Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats. Phytother Res. (2021).
• Sanguis Draconis resin stimulates osteoblast alkaline phosphatase activity and mineralization in MC3T3-E1 cells. J Ethnopharmacol. (2012).