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Humulus Japonicus SNEDDS
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Humulus Japonicus SNEDDS

Humulus Japonicus SNEDDS

Research Snippets (2-8)

16 reviews

$28.00 USD
$28.00 USD $49.99 USD
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Humulus Japonicus SNEDDS

A high bioavailability botanical extract designed to modulate key physiological pathways, including JAK2/STAT5/IGF-1. It separates itself from other height botanicals as it is the only one shown to modulate these directly, practically considered the gold standard cascades for bone growth. Ossialabs uses a Self nano-emulsifying dietary delivery system (SNEDDS) that is shown to increase the bioavailability and permeability of active lipophilic botanical compounds. It is shown in literature to also help bypass first-pass metabolism and leads more compound to be usable.

The SNEDDS Advantage

Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science by solving this bioavailability gap.

  • Straight to the Bloodstream. Ossialabs uses a Self nano-emulsifying dietary delivery system (SNEDDS) that dramatically increases the bioavailability and permeability of active compounds. This helps bypass first-pass metabolism, allowing a significant amount of the botanical compound to go straight into the bloodstream.
  • Superior to Powders: The supplement industry uses raw plant extracts or dry powder extracts that are in many cases very ineffective. By using pre-formulated delivery systems, more product can be used by your body at a time.

Growth Mechanisms & Science

Recent preclinical papers (May 2025 release) have highlighted H. japonicus for its significant potential in bone growth promotion.

Important: H. japonicus is highly dose-dependent. Ensure growth plates are monitored for optimal height objectives.

  • Preclinical Mechanisms. Findings point towards the modulation of IGF-1 and Growth Hormone (GH) levels, acting via the JAK2/STAT5/IGF-1 pathways to support skeletal integrity.
  • Data & Patents. In controlled studies, high-dose groups demonstrated significant longitudinal bone growth rate increases, with femur and tibia length enhancements comparable to the Growth Hormone (GH) control group. Micro-CT scans also revealed significantly denser trabecular bone microarchitecture. Furthermore, the extract is backed by a recognized U.S. Patent for its composition in promoting height growth.
  • Window of Opportunity. Research suggests maximum efficacy for height increase during puberty and while growth plates are still open.

Systemic Health Benefits

Beyond its primary applications, Humulus japonicus provides a comprehensive suite of health-promoting benefits documented in modern scientific literature.

  • Antioxidative & Anti-Aging. The botanical extract exhibits exceptionally strong antioxidative properties. It actively modulates the critical AMPK-SIRT1 pathway, which is highly associated with cellular longevity, energy homeostasis, and defending against oxidative stress and premature aging.
  • Inflammation Modulation. Rich in natural flavonoids and phenolic compounds, it helps the body manage systemic inflammation, promoting better recovery and daily wellness.
  • Proven Bioactives. By using SNEDDS to close the bioavailability gap, proven health benefits including respiratory clearance, neuroprotection, hepatoprotective function, antimicrobial action, anti-obesity mechanisms, gastrointestinal support, and tyrosinase inhibition are significantly amplified compared to standard extractions.
Sleep Support
Respiratory Health
Anti-Inflammatory
Antioxidant
Neuroprotective
Hepatoprotective
Anti-Aging
Bone Promotion

Care, Usage & Taste Profile

  • Do NOT: Do not refrigerate. Do not place near the sun or in super warm liquids. Do NOT shake if the product is already diluted.
  • You CAN: Take Japonicus by itself or put it in water to drink. You can drink other beverages before or after taking it.
  • Best Time. Many customers prefer to take it before sleep.
  • Taste Profile. This is an advanced formulated product without sugary fillers. Some users find the excipients strong, while others don't mind it. It is an acquired taste you will get used to.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.

How long will your bottle last?

Daily Dose 30mL Bottle 60mL Bottle
0.5 mL (Low) 2 Months 4 Months
1.0 mL 1 Month 2 Months
1.5 mL 20 Days 40 Days
2.0 mL (Max) 2 Weeks 1 Month

Note: 10 drops is approximately 0.5 mL. Max recommended dose is 2mL/day.

Key Research & References

  • Kim OK, Yun JM, Lee M, Park SJ, Kim D, Oh DH, Kim HS, Kim GY. A Mixture of Humulus japonicus Increases Longitudinal Bone Growth Rate in Sprague Dawley Rats. Nutrients. 2020 Aug 28;12(9):2625.
  • Park SH, Park J, Yoo JY, Kim HS, Lee M, Kim OK. Humulus japonicus Enhances Bone Growth and Microarchitecture in Rats: Potential Involvement of IGF-1 Signaling. J Med Food. 2025 Jun;28(6):542-552.
  • Kim, O. K., et al. (2023). Food composition for promoting height growth and pharmaceutical composition for promoting height growth including Humulus japonicus extract. U.S. Patent Application No. 18/456,888. Washington, DC: U.S. Patent and Trademark Office.
  • Sung B, Chung JW, Bae HR, Choi JS, Kim CM, Kim ND. Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway. Exp Ther Med. 2015 May;9(5):1819-1826. doi: 10.3892/etm.2015.2302. Epub 2015 Feb 17. PMID: 26136899; PMCID: PMC4471809.

© Ossialabs — Advanced Research Formulations.
Statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.