The SNEDDS Advantage

Humulus japonicus is naturally lipophilic, making it difficult to absorb. Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science by solving this gap.

• Straight to the Bloodstream. Ossialabs uses a Self nano-emulsifying dietary delivery system (SNEDDS) that dramatically increases the bioavailability and permeability of active compounds. This helps bypass first-pass metabolism, allowing a significant amount of the botanical compound to go straight into the bloodstream.
• Superior to Powders. By closing the bioavailability gap, our SNEDDS formulation achieves much more accurate and potent results than taking standard botanical "powders."

Experimental Research & Support

Recent preclinical papers (May 2025 release) have highlighted H. japonicus for its significant potential in bone growth promotion.

Important: Japonicus is highly dose-dependent. You need to make sure your growth plates are opened if you are wanting to get some height gains.

• We Are The Human Studies. Rat studies are mainly used to identify promising botanicals. While rat and human digestion differ, botanical compounds can and do modulate biological pathways across species. By using SNEDDS to solve the human digestion gap, we are testing its true potential. This product is strictly experimental. Our community is serving as the early human studies, with formal trials planned for the future, but it has already shown great promise for those who use it.
• Preclinical Mechanisms. Findings point towards the modulation of IGF-1 and Growth Hormone (GH) levels, acting via the JAK3/STAT5/IGF1 pathways to support vertical growth and bone health.
• Preclinical Data & Patents. In controlled studies, high-dose groups demonstrated significant longitudinal bone growth rate increases, with femur and tibia length enhancements comparable to the Growth Hormone (GH) control group. Micro-CT scans also revealed significantly denser trabecular bone microarchitecture. Furthermore, the extract is backed by a recognized U.S. Patent for its composition in promoting height growth.
• Window of Opportunity. Research suggests maximum efficacy for height increase during puberty and while growth plates are still open.

Care, Usage & Taste Profile

• Do NOT: Do not refrigerate. Do not place near the sun or in super warm liquids. Do NOT shake if the product is already diluted.
• You CAN: Take Japonicus by itself or put it in water to drink. You can drink other beverages before or after taking it.
• Best Time. Many customers prefer to take it before sleep.
• Taste Profile. This is an advanced formulated product without sugary fillers. Some users (including the founder) find the excipients strong, while others don't mind it. It is an acquired taste you will get used to.

Beyond Bone: Systemic Health

Even outside of growth modulation, Humulus japonicus remains a powerhouse ingredient with a wide range of documented health benefits. Recent studies demonstrate that the extract exhibits powerful antioxidative and anti-aging effects through the modulation of the AMPK-SIRT1 pathway.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.

How long will your bottle last?

Note: 10 drops is approximately 0.5 mL. Max recommended dose is 2mL/day.

Key Research & References

Our formulation is based on the following recent preclinical studies and patents:

• Kim OK, Yun JM, Lee M, Park SJ, Kim D, Oh DH, Kim HS, Kim GY. A Mixture of Humulus japonicus Increases Longitudinal Bone Growth Rate in Sprague Dawley Rats. Nutrients. 2020 Aug 28;12(9):2625.
• Park SH, Park J, Yoo JY, Kim HS, Lee M, Kim OK. Humulus japonicus Enhances Bone Growth and Microarchitecture in Rats: Potential Involvement of IGF-1 Signaling. J Med Food. 2025 Jun;28(6):542-552.
• Kim, O. K., et al. (2023). Food composition for promoting height growth and pharmaceutical composition for promoting height growth including Humulus japonicus extract. U.S. Patent Application No. 18/456,888. Washington, DC: U.S. Patent and Trademark Office.
• Sung B, Chung JW, Bae HR, Choi JS, Kim CM, Kim ND. Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway. Exp Ther Med. 2015 May;9(5):1819-1826.