The SNEDDS Advantage

Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science with what we have, unlike the standard supplement industry.

• Straight to the Bloodstream. Ossialabs uses a Self nano-emulsifying dietary delivery system (SNEDDS) that literally increases the bioavailability and permeability of active botanical compounds. This helps bypass first-pass metabolism and leads to a good amount of the botanical compounds going straight to the bloodstream.
• Superior to Powders. Rat studies are mainly used to choose a botanical. While we know rats aren't similar in gut and human digestion, active botanical compounds CAN modulate pathways. By pushing SNEDDS predominantly to close that bioavailability gap, we can achieve more accurate results than just taking "powder".
• We Are The Human Studies. Osstivia SNEDDS is strictly experimental, and our community serves as the early human studies. It shows great promise for the people who have used it, and we plan on conducting formal studies in the future.

Growth Mechanisms & Science

Important: Osstivia is both dose and time dependent. Consistent application is required to trigger the growth pathways.

Based on data. To include preclinical and emerging clinical data:

• Clinical Human Trials. A clinical trial involving women taking FLL powder documented significant improvements in bone mineral density. While this study utilized a basic milk powder delivery, it demonstrates massive potential. By utilizing SNEDDS to bypass first-pass metabolism and send compounds straight to the bloodstream, we are engineered to achieve even greater results.
• Targeted Pathways. Osstivia acts directly on critical bone modulation pathways. Deep pharmacological research shows FLL strongly influences the RANKL-RANK/TRAF6-NF-kB/MAPK-NFATc1 axis, suppressing marrow adipogenesis and increasing ALP for mineralization. It also engages the PI3K/Akt-RUNX2/OPN and MMP-mediated ECM turnover networks.
• Canonical Wnt & BMP-2 Modulation. The enhanced, 3X concentrated Fructus Ligustri Lucidi in the formulation modulates canonical Wnt/β-catenin and BMP-2/Smad pathways, promoting osteoblastogenesis while decreasing osteoclast drive, Nox4/ROS, and oxidative stress.
• Calcium Optimization. Studies show FLL improves calcium retention, absorption, and deposition by upregulating the PTH/VDR/TRPV6 axis, creating a superior mineralization environment.
• Natural Anabolic Muscle Support. Osstivia contains compounds native to FLL like Ursolic Acid, Oleanolic Acid, and Salidroside. These botanical components function as a natural anabolic, providing promising evidence for supporting muscle health and function. While their role in muscle is well-supported, structural bone changes from these specific isolates are not yet heavily documented in humans.

Mandatory Synergy Protocol for Facial Aesthetics

Osstivia provides the boost, but mechanical loading provides the results. For facial aesthetics and condyle growth & remodeling, hard chewing is mandatory.

"If I can demonstrate that chewing alone could change mandible morphology, even if slightly, would you concede that having a supplement that promotes osteoblast activity would improve chewing alone?"

• 30 Minute Limit. Chew for a total of 30 minutes a day. Do NOT chew for hours or constantly clench, as this leads to TMJD and has negative effects on the condyle.
• Cheekbone & Mandible. Hard chewing grows and remodels the condyle, which leads to improvements in the mandible. That is the growth site of the mandible, that's where growth and rotation happens, and its growth affects chin projection. You MAY potentially get zygo improvements since the zygomatic bones are strained when chewing, which can lead to morphological changes. The reason it might change is because chewing provides dynamic oscillative strain to surrounding sutures. Osstivia is there to increase the rate of chewing results and boost chewing results, so pairing Osstivia with chewing is needed for better results. So, hard chewing with Osstivia will help with chin projection because you are growing the condyle.
• Growth Potential. Hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible, so keeping bone health up definitely helps take advantage of that. If it increases proliferation, which Osstivia does, it would be enough to boost chewing results. You're not done remodeling the condyle even after your 60s. However, growth is most potent now, so take advantage of being young and hard chew.
• Timing. Take Osstivia 10–20 minutes BEFORE your hard chewing session for maximum uptake.

How to Chew Correctly (Hard Gum)

• Form & Focus. Open mouth while chewing. Don’t be distracted; focus on the movement.
• Technique. Chew bilaterally (both sides). Position the gum, bite a couple of times, roll the gum with your tongue, and repeat.
• Pacing & Rest. Take rests in between. For example, chew for 1 minute, then rest for 45s–1 min. Rinse and repeat until you hit 30 minutes. Do NOT chew for more than 30 minutes total (including rest time).
• Keep it Tough. If the gum gets soft, use ice water and let it sit in your mouth for a couple of seconds, then resume chewing.
• Safety Note. If you have an overbite, contact the Craniofacial Research Collective (CRC) first before chewing.

Care, Usage & Taste Profile

• Do NOT: Do not refrigerate. Do not place near the sun. Do not put in super warm liquids. Do NOT shake if the product is already diluted.
• You CAN: Take Osstivia by itself or put it in water to drink. You can drink other beverages before or after taking it. You can shake the bottle before use (undiluted).
• Safety & Toxicology. Osstivia has had no negative side effects reported at all. The botanical compound is well tolerated even in high amounts (though please follow the dosing guide and do not overdose). We encourage you to look into Fructus Ligustri Lucidi toxicology, as extensive studies show it is remarkably safe and lacks systemic toxicity.
• Taste Profile. This is an advanced formulated product; it does not taste sugary or fake. Some users are sensitive to the excipients, while others don't mind. It is an acquired taste you will get used to.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.

How long will your bottle last?

Scientific References

• Chen et al. Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety. Molecules. 2017;22:1469.
• Xu et al. Fructus Ligustri Lucidi ethanol extract inhibits osteoclastogenesis in RAW264.7 cells via the RANKL signaling pathway. Molecular Medicine Reports. 2016;14:4767-4774.
• Kong et al. The potential mechanism of Fructus Ligustri Lucidi promoting osteogenetic differentiation of BMSCs based on network pharmacology, molecular docking and experimental identification. Bioengineered. 2022;13:10640-10653.
• Chen, B., Wei, J., Zhu, R., et al. (2021). Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats. Journal of Ethnopharmacology, 279, 114348.
• Tang XF, Ma ZT, Gao YY, et al. Systemic osteoprotective effects of Epimedii Folium and Ligustri Lucidi Fructus in senile osteoporosis rats by promoting the osteoblastogenesis and osteoclastogenesis based on MLP-ANN model. Chin Med. 2020;15:87.
• Li L, Chen B, Zhu R, et al. Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). 2019;11(21):9348-9368.
• Chen L, Huang D, Jiang L, et al. A review of botany, phytochemistry, pharmacology, and applications of the herb with the homology of medicine and food: Ligustrum lucidum W.T. Aiton. Front. Pharmacol. 2024;15:1330732.
• A Milk Product Supplemented with a Herbal Extract for the Prevention of Osteoporosis: Justifications and Clinical Trial. Leung et al. Journal of Food and Nutrition Sciences. (2015).
• Kapoor et al. Biomolecular signals in mandibular condylar cartilage: Bioinformatics and evidence-based insights for optimizing functional appliance therapy. Seminars in Orthodontics. 2025.
• Yang and Ren. Factors Involved in Mandibular Condylar Growth: An Overview. Oral Health and Dental Management. 2014;13:1019-1023.
• Yang et al. Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Clinical Oral Investigations. 2020;24:3547-3557.
• FLL osteoporosis studies summarized in FLL pharmacology and bone-quality literature, including canonical Wnt/beta-catenin signaling.
• Osteoblast-osteoclast communication and OPG/RANKL/cathepsin K pathways reported in FLL bone-remodeling studies.
• PTHrP/Ihh/Sox9 condylar growth axis described in mandibular condylar cartilage growth and MCC development literature.
• Ligustri Lucidi Fructus postmenopausal osteoporosis studies identifying BMP-Smad/Runx2-related mechanisms.
• FLL bone studies reporting Nrf2/HO-1 and ferroptosis-related osteoporosis mechanisms.