The SNEDDS Advantage

Active botanical compounds like Dioscin and Diosgenin are highly beneficial, but they are naturally lipophilic, meaning they have poor absorption on their own. We formulated this product using a Self-Nanoemulsifying Dietary Delivery System (SNEDDS) with specialized excipients to bypass this issue.

SNEDDS literally increases the bioavailability and permeability of active botanical compounds. It helps bypass first-pass metabolism and leads to a good amount of the botanical compounds going straight to the bloodstream. It is formulated for enhanced dispersion, engineered for better delivery so your body can actually absorb the active botanical compounds efficiently.

Training Performance & Support

Diosgenin has a molecular structure remarkably similar to that of DHEA.

• Supports Muscle Function. When combined with resistance training, standardized Dioscorea has been researched for its ability to support exercise readiness and overall muscle quality.
• Anabolic Ceiling. Diosgenin carries strong theoretical potential as a natural anabolic for muscle, it is a steroidal sapogenin with meaningful anabolic signaling properties. While Osstivia currently holds more published muscle data (Ursolic Acid, Oleanolic Acid, Salidroside), Diosgenin's overall ceiling for muscle support may be even higher.
• Standardized Extract. Engineered for better delivery, this formulation provides a highly concentrated, standardized dose (>40% Diosgenin) to ensure consistent support without the drawbacks of synthetic harsh compounds.

Neuroprotection & Cognitive Performance

Diosgenin demonstrates remarkable neuroprotective potential, unlocking new possibilities for brain health when bioavailability is optimized.

• Brain Bioavailability. The historical issue with Diosgenin for brain diseases has been absorption. However, a recent paper demonstrated that utilizing a SNEDDS formulation drastically increased the brain bioavailability of Diosgenin in mouse models, showing immense promise for human use.
• Cognitive Support. Beyond theoretical models, placebo-controlled human trials have shown that Dioscorea extracts provide meaningful improvements in cognitive performance, demonstrating strong potential for overall neuro-support.

Metabolic Conditioning

• Glucose Metabolism. Dioscorea has been studied for its role in upregulating GLUT-4 signaling and translocation, which supports healthy glucose metabolism and systemic balance.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL) for ease of use. Start Low: We recommend starting at 0.5 mL and building up to the maximum dose of 2.0 mL daily.

How long will your bottle last?

Note: 10 drops is approximately 0.5 mL. Max recommended dose is 2mL/day.

Scientific References

• Tohda C, Yang X, Matsui M, Inada Y, Kadomoto E, Nakada S, Watari H, Shibahara N. Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults. Nutrients. 2017 Oct 24;9(10):1160. doi: 10.3390/nu9101160.
• Inada, Y., Tohda, C., Sasabayashi, D., & Suzuki, M. (2024). Diosgenin-rich Yam (rhizome of Dioscorea batatas) extract ameliorates cognitive functions and plasma biomarkers for mild cognitive impairment and mild Alzheimer's disease: A randomized controlled trial. Phytomedicine Plus, 4(3), 100613.
• Ahmad, Niyaz, et al. "Formulation of a novel diosgenin-loaded nanoemulsion and its evaluation for improved brain bioavailability in the management of cerebral ischemia." Journal of Drug Delivery Science and Technology, vol. 114, 2025, p. 107468.
• Kostov T, Diel P, Isenmann E. Examination of the anabolic activity and mechanisms of action of the combination of Diosgenin and Ecdysterone in C2C12 myotubes. Toxicol Lett. 2024 Nov;401:181-189. doi: 10.1016/j.toxlet.2024.10.005.
• Horii N, Hasegawa N, Fujie S, Iemitsu K, Uchida M, Hamaoka T, Iemitsu M. Effects of Dioscorea esculenta intake with resistance training on muscle hypertrophy and strength in sprint athletes. J Clin Biochem Nutr. 2020 Nov;67(3):338-343. doi: 10.3164/jcbn.19-124.
• Semwal P, Painuli S, Abu-Izneid T, Rauf A, Sharma A, Daştan SD, Kumar M, Alshehri MM, Taheri Y, Das R, Mitra S, Emran TB, Sharifi-Rad J, Calina D, Cho WC. Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives. Oxid Med Cell Longev. 2022 May 29;2022:1035441.
• ur-Rehman, R., et al. "Diosgenin: A Potential Therapeutic Phytocompound for the Management of Atherosclerosis and Other Physiological Disorders." Natural Product Communications, 2024.
• Wang Z, Zhao S, Tao S, Hou G, Zhao F, Tan S, Meng Q. Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic Diseases. Molecules. 2023 Mar 22;28(6):2878.
• Mohseni-Moghaddam P, Khanmohammadi M, Roghani M. Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action. Front Pharmacol. 2023 Sep 12;14:1226548.
• Biswas, Soumili, et al. "Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders." Brain Behavior and Immunity Integrative, vol. 7, 2024, p. 100069.
• Sato et al. Dioscorea esculenta-induced increase in muscle sex steroid hormones is associated with enhanced insulin sensitivity in a type 2 diabetes rat model. FASEB Journal. (2017).
• Poole et al. Chronic application and significant increase in 1RM leg press and 1RM bench press during strength training. (2010).
• Ikeuchi et al. (2006); Goh et al. (2020); Herrick et al. (2020). Improvements in endurance capacity in animal models and human interventions.