Humulus Japonicus SNEDDS

An experimental, high-absorption botanical extract based on the latest May 2025 preclinical research. Japonicus is a new experimental botanical that is shown to increase a specific GH pathway cascade known as JAK2/STAT5/IGF-1. It separates itself quite well from other height botanicals as it is the only one that is shown to modulate these directly, which are practically considered gold standard cascades for bone growth. Formulated by Ossialabs to support bone health and promote incredibly potent systemic health benefits. The SNEDDS formula will help increase the bioavailability of these lipophilic compounds.

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The SNEDDS Advantage

Humulus japonicus is naturally lipophilic, making it difficult to absorb. Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science by solving this gap.

Straight to the Bloodstream. Ossialabs uses a Self nano-emulsifying dietary delivery system (SNEDDS) that dramatically increases the bioavailability and permeability of active compounds. This helps bypass first-pass metabolism, allowing a significant amount of the botanical compound to go straight into the bloodstream.
Superior to Powders. By closing the bioavailability gap, our SNEDDS formulation achieves much more accurate and potent results than taking standard botanical "powders."

Experimental Research & Support

Recent preclinical papers (May 2025 release) have highlighted H. japonicus for its significant potential in bone growth promotion.

Important: Japonicus is highly dose-dependent. You need to make sure your growth plates are opened if you are wanting to get some height gains.

Community-Led Research. Rat studies are mainly used to identify promising botanicals. While rat and human digestion differ, botanical compounds can and do modulate biological pathways across species. By using SNEDDS to solve the human digestion gap, we are testing its true potential. Our community is leading the way in real-world application, with formal trials planned for the future.
Preclinical Mechanisms. Findings point towards the modulation of IGF-1 and Growth Hormone (GH) levels, acting via the JAK3/STAT5/IGF1 pathways to support vertical growth and bone health.
Preclinical Data & Patents. In controlled studies, high-dose groups demonstrated significant longitudinal bone growth rate increases, with femur and tibia length enhancements comparable to the Growth Hormone (GH) control group. Micro-CT scans also revealed significantly denser trabecular bone microarchitecture. Furthermore, the extract is backed by a recognized U.S. Patent for its composition in promoting height growth.
Window of Opportunity. Research suggests maximum efficacy for height increase during puberty and while growth plates are still open.

Beyond Bone: Systemic Health

While Japonicus is experimental for skeletal changes and height, its broader systemic health applications are heavily proven and incredibly well-documented in literature.

We want to be clear: the metabolic and cellular health benefits of Humulus Japonicus are proven and much better backed up than the potential for height gains.

Antioxidative & Anti-Aging. The botanical extract exhibits exceptionally strong antioxidative properties. It actively modulates the critical AMPK-SIRT1 pathway, which is highly associated with cellular longevity, energy homeostasis, and defending against oxidative stress and premature aging.
Inflammation Modulation. Rich in natural flavonoids and phenolic compounds, it helps the body manage systemic inflammation, promoting better recovery and daily wellness.
Proven Bioactives. By using SNEDDS to close the bioavailability gap, these proven health benefits are significantly amplified compared to standard extractions.

Anti-Inflammatory

Antioxidant

Neuroprotective

Anti-Aging

Bone Promotion

Gut Support

Care, Usage & Taste Profile

Do NOT: Do not refrigerate. Do not place near the sun or in super warm liquids. Do NOT shake if the product is already diluted.
You CAN: Take Japonicus by itself or put it in water to drink. You can drink other beverages before or after taking it.
Best Time. Many customers prefer to take it before sleep.
Taste Profile. This is an advanced formulated product without sugary fillers. Some users (including the founder) find the excipients strong, while others don't mind it. It is an acquired taste you will get used to.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.

How long will your bottle last?

Daily Dose	30mL Bottle	60mL Bottle
0.5 mL (Low)	2 Months	4 Months
1.0 mL	1 Month	2 Months
1.5 mL	20 Days	40 Days
2.0 mL (Max)	2 Weeks	1 Month

Note: 10 drops is approximately 0.5 mL. Max recommended dose is 2mL/day.

Key Research & References

Our formulation is based on the following recent preclinical studies and patents:

Kim OK, Yun JM, Lee M, Park SJ, Kim D, Oh DH, Kim HS, Kim GY. A Mixture of Humulus japonicus Increases Longitudinal Bone Growth Rate in Sprague Dawley Rats. Nutrients. 2020 Aug 28;12(9):2625.
Park SH, Park J, Yoo JY, Kim HS, Lee M, Kim OK. Humulus japonicus Enhances Bone Growth and Microarchitecture in Rats: Potential Involvement of IGF-1 Signaling. J Med Food. 2025 Jun;28(6):542-552.
Kim, O. K., et al. (2023). Food composition for promoting height growth and pharmaceutical composition for promoting height growth including Humulus japonicus extract. U.S. Patent Application No. 18/456,888. Washington, DC: U.S. Patent and Trademark Office.
Sung B, Chung JW, Bae HR, Choi JS, Kim CM, Kim ND. Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway. Exp Ther Med. 2015 May;9(5):1819-1826. doi: 10.3892/etm.2015.2302. Epub 2015 Feb 17. PMID: 26136899; PMCID: PMC4471809.

© Ossialabs — Advanced Research Formulations.
Statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.