The SNEDDS Advantage

Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science with what we have, unlike the standard supplement industry.

• Straight to the Bloodstream. Ossialabs uses a Self-Nanoemulsifying Drug Delivery System (SNEDDS) that literally increases the bioavailability and permeability of active compounds. This helps bypass first-pass metabolism and leads to a good amount of the compounds going straight to the bloodstream.
• Superior to Powders. Rat studies are mainly used to choose a botanical. While we know rats aren't similar in gut and human digestion, active compounds CAN modulate pathways. By pushing SNEDDS predominantly to close that bioavailability gap, we can achieve more accurate results than just taking "powder".
• We Are The Human Studies. Osstivia SNEDDS is strictly experimental, and our community serves as the early human studies. It shows great promise for the people who have used it, and we plan on conducting formal studies in the future.

Growth Mechanisms & Science

Important: Osstivia is both dose and time dependent. Consistent application is required to trigger the growth pathways.

Based on data. To include preclinical:

• Targeted Pathways. Osstivia acts directly on critical bone modulation pathways, including downregulating RANKL/NFATc1 to inhibit osteoclast formation, and increasing ALP for mineralization. Botanical compounds can successfully modulate these pathways; even if it primarily increases cellular proliferation, it would be enough to boost chewing results.
• Canonical Wnt & MAPK Modulation. The enhanced Fructus Ligustri Lucidi in the formulation modulates canonical Wnt/β-catenin and MAPK/Akt pathways, promoting osteoblastogenesis while decreasing osteoclast drive and oxidative stress.
• Calcium Optimization. Studies show it improves calcium retention, absorption, and deposition by upregulating the PTH/VDR/TRPV6 axis, creating a superior mineralization environment.
• Natural Anabolic Muscle Support. Osstivia contains compounds like Ursolic Acid, Oleanolic Acid, and Salidroside. These botanical components function as a natural anabolic, providing promising evidence for supporting muscle health and function. While their role in muscle is well-supported, structural bone changes from these specific isolates are not yet heavily documented in humans.

Mandatory Synergy Protocol for Facial Aesthetics

Osstivia provides the boost, but mechanical loading provides the results. For facial aesthetics and condyle growth & remodeling (as well as zygomatic improvements), hard chewing is mandatory.

• 30 Minute Limit. Chew for a total of 30 minutes a day. Do NOT chew for hours or constantly clench, as this leads to TMJD and has negative effects on the condyle.
• Cheekbone & Mandible. The zygomatic bones are strained when chewing, which can lead to morphological changes. Hard chewing grows and remodels the condyle, which leads to greater improvements in the mandible. Osstivia helps with forward growth and CCW rotation of the mandible under specific circumstances like malocclusion and a good tough chewing regimen. Some zygo and mandible improvements may be possible but it needs to be looked into further. Basically, Osstivia boosts hard chewing results and reduces the time to get those results.
• Growth Potential. Hypertrophic growth cartilage and condyle remodeling exists even after puberty in the mandible, so keeping bone health up definitely helps take advantage of that. If it increases proliferation, which Osstivia does, it would be enough to boost chewing results. You're not done remodeling the condyle even after your 60s. However, growth is most potent now, so take advantage of being young and hard chew.
• Timing. Take Osstivia 10–20 minutes BEFORE your hard chewing session for maximum uptake.

How to Chew Correctly (Hard Gum)

• Form & Focus. Open mouth while chewing. Don’t be distracted; focus on the movement.
• Technique. Chew bilaterally (both sides). Position the gum, bite a couple of times, roll the gum with your tongue, and repeat.
• Pacing & Rest. Take rests in between. For example, chew for 1 minute, then rest for 45s–1 min. Rinse and repeat until you hit 30 minutes. Do NOT chew for more than 30 minutes total (including rest time).
• Keep it Tough. If the gum gets soft, use ice water and let it sit in your mouth for a couple of seconds, then resume chewing.
• Safety Note. If you have an overbite, contact the Craniofacial Research Collective (CRC) first before chewing.

Care, Usage & Taste Profile

• Do NOT: Do not refrigerate. Do not place near the sun. Do not put in super warm liquids. Do NOT shake if the product is already diluted.
• You CAN: Take Osstivia by itself or put it in water to drink. You can drink other beverages before or after taking it. You can shake the bottle before use (undiluted).
• Taste Profile. This is an advanced formulated product; it does not taste sugary or fake. Some users are sensitive to the excipients, while others don't mind. It is an acquired taste you will get used to.

New Measurement Dosing System

We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the max of 2.0 mL.

How long will your bottle last?

Scientific References

• Fructus ligustri lucidi ethanol extract improves bone mineral density and properties through modulating calcium absorption-related gene expression in kidney and duodenum of growing rats. Calcif Tissue Int. (2014).
• The advances in research on the pharmacological effects of Fructus Ligustri Lucidi. Biomed Res Int. (2015).
• Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri Lucidi. Br J Nutr. (2008).
• Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). (2019).
• Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats. Phytother Res. (2021).
• Sanguis Draconis resin stimulates osteoblast alkaline phosphatase activity and mineralization in MC3T3-E1 cells. J Ethnopharmacol. (2012).