Osstivia SNEDDS (Gen 3)
A high bioavailability evolution of Fructus Ligustri Lucidi Extract, now upgraded with Vitamin D3 and K2 (MK-7). Powered by a complex of bioactive compounds including Oleanolic Acid, Ursolic Acid, Salidroside, Nuzhenide, Specnuezhenide, Oleuropein, Echinacoside, and Vitamin D3 + K2 (MK-7), Osstivia uses a Self-nanoemulsifying dietary delivery system (SNEDDS) to massively increase the permeation of these highly lipophilic compounds. This comprehensive formulation is engineered to actively promote bone growth, trigger remodeling, increase bone density, stimulate osteoblast activity, and aggressively inhibit osteoclasts.
Gen 3 Formula Update (Pre-Order)
Osstivia has entered a temporary Pre-Order stage to undergo a massive Generation 3 formulation upgrade. We are introducing Vitamin D3 and Vitamin K2 (MK-7) directly into our SNEDDS matrix, engineering a complete, highly bioavailable system for advanced bone growth and active remodeling in a single bottle. This is built on top of our strict Standardized Extract verified by HPLC to contain 20% Oleanolic Acid. This new formulation delivers a significantly higher concentration of total extract per mL compared to the legacy version. Note: Pre-order fulfillment will operate on a strict first come, first served basis.
View 20% Oleanolic Acid CoA
Color differences between legacy Osstivia (left), and new Osstivia (right). Expect a huge improvement and increased value for your purchase.
Ossialabs uses a Self-nanoemulsifying dietary delivery system (SNEDDS) that is shown to increase the bioavailability and permeability of active lipophilic botanical compounds. It is shown in literature to also help bypass first-pass metabolism and leads more compound to be usable.
The SNEDDS Advantage
Average supplements cannot bypass first-pass metabolism and end up destroyed during digestion. We are actively advancing the science with what we have, unlike the standard supplement industry. Click the boxes below to expand details.
Straight to the Bloodstream
Ossialabs uses a Self-nanoemulsifying dietary delivery system (SNEDDS) that literally increases the bioavailability and permeability of active botanical compounds. This helps bypass first-pass metabolism and leads to a good amount of the botanical compounds going straight to the bloodstream.
Superior to Powders
The supplement industry uses raw plant extracts or dry powder extracts that are in many cases very ineffective. By using pre-formulated delivery systems, more product can be used by your body at a time.
Vitamin K2 (MK-7) Emulsion
Menaquinone-7 (MK-7) acts at the extrahepatic level in support of critical pathways involved in bone and cardiovascular health, including osteocalcin deposition. Because MK-7 has limited solubility in aqueous solutions, its in vivo bioavailability can be heavily restricted. Formulation strategies strongly affect the bioavailability of MK-7. Delivering MK-7 as an oil-water emulsion greatly improves its absorption results. In fact, AUC analysis over 8 hours demonstrated a highly significant increase in bioavailability for the emulsified formula compared to a standard powder suspension. Pharmacokinetics of MK-7 show a massive spike in plasma levels at 2 hours when using an emulsion compared to no emulsion.
Vitamin D3 Oral Solution
Cholecalciferol (Vitamin D3) oral solutions show significantly higher bioavailability parameters (AUC and Cmax) compared to standard soft gelatin capsules. The ratio for the area under the concentration-time curve (AUC) was 136.43%, and the maximum observed drug concentration (Cmax) was 142.83% higher for the liquid solution.
SNEDDS Permeation Models
FLL Pathway Breakdown
From the Documentation: A deep dive into the specific molecular pathways modulated by Fructus Ligustri Lucidi (FLL) and how Osstivia amplifies these effects.
Osstivia acts as an amplified, highly bioavailable version of FLL. By using a SNEDDS formulation, it bypasses digestion to saturate these critical pathways far more effectively than standard extractions or powders.
Wnt/β-catenin & BMP-Smad Signaling
FLL active compounds strongly upregulate Wnt and BMP-2 pathways. This triggers the expression of RUNX2 and Osterix (Osx), the master transcription factors for differentiation. In simple terms: it signals your body to increase the production of new matrix.
OPG/RANKL/RANK Axis
FLL significantly improves the OPG/RANKL ratio. By downregulating RANKL expression and upregulating Osteoprotegerin (OPG), it prevents the activation of NF-κB and MAPK pathways. This effectively suppresses excessive tissue breakdown.
PI3K/Akt Pathway & Antioxidant Defense
FLL activates PI3K/Akt signaling, which promotes cellular survival and proliferation. It also engages antioxidant defenses (like the Nrf2/HO-1 axis) to protect cells from oxidative stress and apoptosis, making sure your cells remain healthy.
Calcium Homeostasis (TRPV6/VDR)
The compounds modulate the parathyroid hormone (PTH) and Vitamin D receptor (VDR) networks. This upregulates TRPV6 to dramatically increase intestinal and cellular calcium absorption, making sure the raw materials are readily available for mineralization.
The Osstivia Synergy
While traditional FLL requires massive doses to survive gut processing, Osstivia's SNEDDS formulation delivers these specific active constituents directly into the bloodstream for optimal systemic bone support.
The Active Compounds
Osstivia's raw power is driven by the synergistic presence of these specific bioactive compounds, highly concentrated and delivered via our nano-emulsion system:
Nuzhenide & Specnuezhenide
These potent secoiridoids are unique to FLL. They are the primary biological drivers for stimulating osteoblast proliferation, significantly enhancing alkaline phosphatase (ALP) activity, and tightly regulating systemic calcium metabolism within the bone matrix.
Oleanolic Acid (OA)
A powerful triterpenoid that directly stimulates the Wnt/β-catenin and BMP-2 signaling pathways to promote rapid bone formation and matrix mineralization, while also acting as a profound metabolic and liver protectant.
Ursolic Acid (UA)
Functions as a natural anabolic for muscle support and actively suppresses osteoclastogenesis by heavily inhibiting the RANKL/NF-κB pathway, effectively halting unnecessary bone tissue breakdown.
Salidroside
An elite adaptogen that engages the PI3K/Akt pathway to promote cellular survival. It stimulates bone marrow mesenchymal stem cells (BMSCs), heavily reduces oxidative stress (ROS), and provides baseline neuroprotection.
Oleuropein & Echinacoside
Highly active polyphenols that drastically enhance the OPG/RANKL ratio (favorable for bone preservation). They mitigate systemic inflammation, scavenge free radicals, and provide extensive cardiovascular and cellular support.
Growth Mechanisms & Science
Important: Osstivia is both dose and time-dependent. Consistent application is required to trigger the growth pathways.
Based on preclinical and emerging clinical data:
Clinical Human Trials
A clinical trial involving women taking FLL powder documented significant improvements in bone mineral density. While this study used a basic milk powder delivery, it demonstrates massive potential. By using SNEDDS to bypass first-pass metabolism and send compounds straight to the bloodstream, we are engineered to achieve even greater results.
Targeted Pathways
Osstivia acts directly on critical pathways. Deep pharmacological research shows FLL strongly influences the RANKL-RANK/TRAF6-NF-κB/MAPK-NFATc1 axis, suppressing marrow adipogenesis and increasing ALP for mineralization. It also engages the PI3K/Akt-RUNX2/OPN and MMP-mediated ECM turnover networks.
Canonical Wnt & BMP-2 Modulation
The enhanced, 3X concentrated Fructus Ligustri Lucidi in the formulation modulates canonical Wnt/β-catenin and BMP-2/Smad pathways, promoting osteoblastogenesis while decreasing osteoclast drive, Nox4/ROS, and oxidative stress.
Calcium Optimization
Studies show FLL improves calcium retention, absorption, and deposition by upregulating the PTH/VDR/TRPV6 axis, creating a superior mineralization environment.
Natural Anabolic Muscle Support
Osstivia contains compounds native to FLL like Ursolic Acid, Oleanolic Acid, and Salidroside. These botanical components function as a natural anabolic, providing promising evidence for supporting muscle health and function. While their role in muscle is well-supported, structural bone changes from these specific isolates are not yet heavily documented in humans.
Clinical Study Data
Beyond Bone: Systemic Health
While Osstivia is engineered for advanced delivery, the highly concentrated Fructus Ligustri Lucidi (FLL) extract offers a massive spectrum of whole-body health benefits heavily documented in scientific literature.
Gut Microbiota & Digestion
FLL has been shown to positively regulate gut microbiota diversity and significantly increase the production of beneficial short-chain fatty acids (SCFAs), creating a healthier digestive environment.
Antioxidant & Anti-Aging Defense
The botanical actively mitigates oxidative stress by engaging the body's natural Nrf2/HO-1 antioxidant pathways. It also modulates Sirt6 and TMAO levels, proteins strongly linked to longevity and protecting against cellular aging.
Systemic Calcium Balance
Beyond localized bone formation, studies show that FLL promotes overall calcium retention and absorption throughout the body, making sure your system has the building blocks it needs.
Macrophage & Immune Regulation
Native to FLL, Ursolic Acid is an invaluable natural nutraceutical that heavily regulates macrophage activity. It actively suppresses pro-inflammatory cytokines and promotes a highly robust, balanced immune response.
Hepatoprotective & Metabolic Health
Verified by HPLC to contain 15-20% Oleanolic Acid, this standardized extract acts as a profound liver protectant. Together with Specnuezhenide, it significantly aids in metabolic conditioning and helps regulate lipid metabolism efficiently.
Neuroprotection & Adaptogenic Shield
The formulation naturally contains a matrix of adaptogenic compounds like Salidroside and Echinacoside, proven to reduce physical fatigue, protect the central nervous system against oxidative damage, and support cognitive vitality while scavenging free radicals.
Gut Support
Anti-Aging
Antioxidant
Calcium Regulation
Immune Modulation
Liver Support
Adaptogenic
Neuroprotective
Learn More
Osstivia is a highly specialized, bioavailability enhanced formulation engineered to actively promote bone growth, amplify natural bone remodeling, and provide comprehensive systemic health support. If you are trying to understand the deeper science, cellular mechanisms, and core purpose behind this advanced botanical extract, read our complete overview.
Read the Full BreakdownCare, Usage & Taste Profile
How to Take It
You take Osstivia orally via the dropper that comes with the bottle. The glass dropper is marked with precise measurements so you can easily track your daily mL dosage.
Do NOT:
Do not refrigerate. Do not place near the sun. Do not put in super warm liquids. Do NOT put it in oil. Do NOT shake if the product is already diluted.
You CAN:
Take Osstivia by itself or put it in water to drink. You can drink other beverages before or after taking it. You can shake the bottle before use (undiluted). Feel free to pair Osstivia with Vitamin D3, K2, and Calcium to help with it even more, since studies show FLL improves calcium retention and deposition.
Safety & Toxicology
There are just reported health benefits and results. There doesn’t seem to be any negative side effects reported even in studies on FLL. The toxicology in FLL is very good. Unlike many other products, this is because the compounds involved are not shown to hurt the liver but help it in normal doses. The compounds are generally safe and still modulate the pathways because it doesn't create an environment like a high affinity drug does. It involves many pathways working together and some balancing others.
Taste Profile
This is an advanced formulated product; it does not taste sugary or fake. Some users are sensitive to the excipients, while others don't mind. It is an acquired taste you will get used to.
New Measurement Dosing System
We have upgraded from drops to a precise measurement dropper (mL). Start Low: We recommend starting at 0.5 mL and building up to the optimal dose of 1.0 to 2.0 mL daily.
Consistency is Key: Because Osstivia is dose and time-dependent, we highly recommend purchasing a pack of 5-6 bottles (60mL) to maintain a consistent 1-2mL daily protocol. (Note: If you have the budget, 2mL or more is basically optimal (obviously don't overdose like crazy). Some users have recently started testing 3-6mL daily as well).
How long will your bottle last?
| Daily Dose | 30mL Bottle | 60mL Bottle |
|---|---|---|
| 0.5 mL (Low) | 2 Months | 4 Months |
| 1.0 mL | 1 Month | 2 Months |
| 1.5 mL | 20 Days | 40 Days |
| 2.0 mL (Max) | 2 Weeks | 1 Month |
Scientific References
- Cirilli I, Orlando P, Silvestri S, Marcheggiani F, Tiano L. Bioavailability of menaquinone-7 in milk formulation. Comparison of different solubilization techniques. Nutrafoods (2019) 1:34-39. DOI 10.17470/NF-019-0005.
- Chen et al. Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety. Molecules. 2017;22:1469.
- Xu et al. Fructus Ligustri Lucidi ethanol extract inhibits osteoclastogenesis in RAW264.7 cells via the RANKL signaling pathway. Molecular Medicine Reports. 2016;14:4767-4774.
- Kong et al. The potential mechanism of Fructus Ligustri Lucidi promoting osteogenetic differentiation of BMSCs based on network pharmacology, molecular docking and experimental identification. Bioengineered. 2022;13:10640-10653.
- Chen, B., Wei, J., Zhu, R., et al. (2021). Fructus Ligustri Lucidi aqueous extract promotes calcium balance and short-chain fatty acids production in ovariectomized rats. Journal of Ethnopharmacology, 279, 114348.
- Tang XF, Ma ZT, Gao YY, et al. Systemic osteoprotective effects of Epimedii Folium and Ligustri Lucidi Fructus in senile osteoporosis rats by promoting the osteoblastogenesis and osteoclastogenesis based on MLP-ANN model. Chin Med. 2020;15:87.
- Li L, Chen B, Zhu R, et al. Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). 2019;11(21):9348-9368.
- Chen L, Huang D, Jiang L, et al. A review of botany, phytochemistry, pharmacology, and applications of the herb with the homology of medicine and food: Ligustrum lucidum W.T. Aiton. Front. Pharmacol. 2024;15:1330732.
- A Milk Product Supplemented with a Herbal Extract for the Prevention of Osteoporosis: Justifications and Clinical Trial. Leung et al. Journal of Food and Nutrition Sciences. (2015).
- Kapoor et al. Biomolecular signals in mandibular condylar cartilage: Bioinformatics and evidence-based insights for optimizing functional appliance therapy. Seminars in Orthodontics. 2025.
- Yang and Ren. Factors Involved in Mandibular Condylar Growth: An Overview. Oral Health and Dental Management. 2014;13:1019-1023.
- Yang et al. Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat. Clinical Oral Investigations. 2020;24:3547-3557.
- FLL osteoporosis studies summarized in FLL pharmacology and bone-quality literature, including canonical Wnt/beta-catenin signaling.
- Osteoblast-osteoclast communication and OPG/RANKL/cathepsin K pathways reported in FLL bone-remodeling studies.
- PTHrP/Ihh/Sox9 condylar growth axis described in mandibular condylar cartilage growth and MCC development literature.
- Ligustri Lucidi Fructus postmenopausal osteoporosis studies identifying BMP-Smad/Runx2-related mechanisms.
- FLL bone studies reporting Nrf2/HO-1 and ferroptosis-related osteoporosis mechanisms.
- Feng, Wenjing, et al. "Progress of Ursolic Acid on the Regulation of Macrophage: Summary and Prospect." Frontiers in Immunology, vol. 16, 2025.
- Wal, Pranay, et al. "Multifunctional Roles and Phytopharmacological Potential of Ursolic Acid: An Invaluable Natural Nutraceutical Agent." Russian Journal of Bioorganic Chemistry, vol. 51, no. 1, 2025.
© Ossialabs Advanced research-backed formulations.
Statements have not been evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
